Computer players have a strong advantage before us humans: the ability to calculate deeper and the huge memory.But there are some human tricks which can "confuse" the machine to make some little mistakes.
One of them is offbeat opening choice and another one is to extremely close the position and start slow maneuvering.
I suppose a superGM can defeat a computer whenever he/she wants. I think that the only losses (in the 21th century) of GMs are just because they like the beauty of the game and they don't want to win just by following a method.
Kibitzing
